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03-Jun-2017 USEARCH v10.0 posted. What's new.

11-Apr-2017 UNBIAS paper: 16S read abundance does not correlate with species abundance!

Search_16S paper: new method for finding 16S genes in chromosomes and contigs.

24-Nov-2016 UPARSE tutorial video posted on YouTube. Make OTUs from MiSeq reads.

19-Nov-2016 UNCROSS paper posted. 2% of Illumina reads are assigned to wrong sample!

USEARCH has been cited by
5,250 papers
Google scholar
Last updated 18 Aug 2017


registered users

64-bit users
Joint Genome Institute
MBL, Woods Hole
Cornell Univ.
CNRS (France)
La Jolla Institute
Ag. Research (NZ)
Broad Institute
UC Davis
UC Berkeley
Pacific Biosystems
and many more.
High-throughput search and clustering
USEARCH is a unique sequence analysis tool with thousands of users world-wide. USEARCH offers search and clustering algorithms that are often orders of magnitude faster than BLAST.
Improved productivity and insights
USEARCH combines many different algorithms into a single package with outstanding documentation and support. This cuts your learning curve, reduces the number of steps you need to take for a given task, and slashes compute times. USEARCH will encourage you to explore your data, enabling new insights and suggesting new analyses that you might not have tried with slower tools.
Free for most users
Licenses to use 32-bit USEARCH are offered at no charge for all users, including commercial. You can download the 32-bit version here.