UPARSE is an OTU clustering algorithm published in Nature
UPARSE generates OTUs that are far superior to state-of-the-art methods
including QIIME, mothur and AmpliconNoise on
community tests. OTU representative sequences are more accurate predictions
of biological sequences, and the number of OTUs is much close to the number of
The UPARSE algorithm is implemented in USEARCH v7 and later.
To get the software, go to the
USEARCH download page.
Edgar, R.C. (2013) UPARSE: Highly accurate OTU sequences from microbial amplicon reads,
Nature Methods [Pubmed:23955772,