UPARSE is a new OTU clustering method recently published in Nature
UPARSE generates OTUs that are far superior to state-of-the-art methods
includeing QIIME, mothur and AmpliconNoise on
community tests. OTU representative sequences are more accurate predictions
of biological sequences, and the number of OTUs is much close to the number of
The UPARSE algorithm is implemented in USEARCH v7.
To get USEARCH v7, go to the
USEARCH download page.
Edgar, R.C. (2013) UPARSE: Highly accurate OTU sequences from microbial amplicon reads,
Nature Methods [Pubmed:23955772,