USEARCH documentation 

USEARCH features and performance
Features.
Performance.

OTU clustering
The otupipe script is provided for high-throughput, high-accuracy OTU clustering based on USEARCH. 

Papers
Edgar,R.C. (2010), Search and clustering orders of magnitude faster than BLAST, Bioinformatics.
doi: 10.1093/bioinformatics/btq461

Edgar,RC, Haas,BJ, Clemente,JC, Quince,C, Knight,R (2011) UCHIME improves sensitivity and speed of chimera detection, Bioinformatics doi: 10.1093/bioinformatics/btr381.

Manuals
How to install and use my command-line programs.
 

Version 5.1 USEARCH manual (PDF).
Version 5.0 USEARCH manual (PDF).
Version 5.0 UCHIME manual (PDF).

Older documentation

OTU clustering
See otupipe home page.

New features and bug reports
Change logs.
 
Other
Comments on comparing CD-HIT and the UCLUST algorithm in USEARCH.